Drug Dissolution Sampling System DW-MDS-2008
MDS-2008 Drug Dissolution sampling system meets the performance indexes of Chinese Pharmacopoeia and 21 CFR Part 11. It is designed for high-end pharmaceutical companies, drug testing centers and scientific research institutes around the world, and consists of Dissolution Tester and Auto sampler. It realizes fully automatic sampling and preservation of samples in drug dissolution test, which can effectively improve the experimental efficiency.
Features of Drug Dissolution Sampling System DW-MDS-2008
Dissolution cup
Embedded retention hoops prevent collisions, reduce evaporation and provide better centering and verticality. Indicator strips on the rim of the cups and diagonal mounts minimize variation between dissolution processes. Dissolution cups are available in 1000mL and 250mL sizes, with the 1000mL size available in a brown, light-proof dissolution cup.
Automatic dosing module
The ingenious design of the automatic dosing module avoids the sticking of tablets, and can realize 8 cups dosing at the same time, and also can take into account the sequence of dosing, which can effectively improve the accuracy of dosing.
Segmented paddle shafts
Using a segmented 316L stainless steel paddle shaft design that includes paddles, rotating baskets, rotating barrels and small volume options allows for the attachment of interchangeable baskets and paddles and eliminates the need for height readjustment before and after conversion, saving significant time.
Built-in printer
The instrument is equipped with a built-in printer,real-time printing log records, the experimental process data records can be audited query, logs can be exported to consult (need to use the company’s special software to open the exported documents).
One click import
100 experimental methods storage space, USB can realize one-click import and export operation,avoiding the tedious steps of method transfer be tween different instruments.
Anti-evaporation cover
considering the impact of solvent evaporation on the experimental results, the MDS-2008Ds is designed with a V-shaped lid that fits perfectly with the dissolution cup to minimize solvent evaporation.
Water bath
0ne-piece injection-molded water baths with quick-connect fittings: Quick-connect fittings and rounded corners that allow the circulating water to be completely emptied save time in cleaning the instrument, preventing dirt and bacteria from being trapped in the seams of conventional water baths.
Stainless steel guide rods
The use of multi-point stainless steel guide bar, excellent to ensure the stability of the machine head, for the dissolution of the cup and the center of the rotary axis of the positioning of the stability to provide strong support for the effective prolongation of the mechanical properties of the stabilization time.
Photosensitive lighting
The instrument has built-in photosensitive illumination, together with the brown dissolution cup, to better realize the experiment of avoiding light.
Certification and technical support
Certification and Technical support: we also provide standards-compliant AIQ certification services,mechanical validation services, and technical and application-related support services such as instrument training and installation training.
Heating circulation system
Relying on the Drawell’s many years of experience in the field of temperature control, MDS-2008DS is equipped with an independently controlled heating circulation system, which can minimize vibration under the condition of saving the volume of the experimental table. The unattended reservation function can realize unmanned automatic thermostatic water bath, saving experiment time.
Temperature probe
Eight cups of independent temperature probe, can realize eight cups of solvent temperature independent monitoring, real-time display, and the temperature probe can be raised during the dissolution experiment, will not interfere with the dissolution experiment. Adopting PID+ fuzzy control, the temperature control accuracy reaches ±0.2oc, and the temperature resolution reaches 0.1oc.
Administrative authority
The MDS-2008DS provides three levels of administrative privileges that meet audit trail requirements,controlling access and blocking unnecessary changes to instrument settings or methods.
Color touch screen
Featuring a 10-inch color touch screen, the touch panel can be easily manipulated to set up, store and run up to 100 methods. The intuitive interface with screen-lock safety feature also offers Chinese and English as language options.
Technical Parameters of Drug Dissolution Sampling System DW-MDS-2008
| Instrument performance indicators | Heating range of water bath: RT-45.0℃ | Instrument Functions | Compatible with basket method, paddle method, small cup method, paddle dish method, and rotating cylinder method. |
| Temperature resolution:0.1℃ | Dissolution cups: 6/8 cups. | ||
| Temperature control accuracy:±0.2℃ | segmented swivel design, no need to readjust the height for switching between basket, paddle and swivel methods. | ||
| Stirring speed range: 10.0-300.0RPM | Automatic synchronized dosing/sequential dosing. | ||
| Speed resolution:0.1RPM | Photosensitive illumination: white/red three-level illumination. | ||
| Speed accuracy:±0.5RPM | More than 100 experimental methods can be stored and imported and exported by USB. | ||
| Instrument Mechanical Indicators | Basket (paddle) shaft swing: ≤0.5mm | 39 login accounts and passwords can be stored, and operating privileges can be controlled at 3 levels. | |
| Swing of rotating basket:≤1.0mm | With operation record printing and logging function, and can audit trail. | ||
| Deviation between rotating shaft and dissolving cup shaft: <±1.5mm | Input power supply | 220VAC士10% 1300w | |
| Dissolution meter level: ≤0.2° | Dimensions | ≈670x565x640mm | |
| Verticality of basket (paddle) shaft: 90±0.5° | Overall weight | ≈65kg | |
| Working humidity | (20~80)% RH | 0peration temperature | (10~30) ℃ |
| Storage humidity | (5~95)% RH | storage temperature | (-20~60) ℃ |
DW-MDS-2008 Auto Sampler
Drug Dissolution sampling system consists of a dissolution tester and an auto sampler. Here are the features:
Fully automated silo doors for one-touch in and out of the silo.
Automatic positioning detection function for test tube racks.
High quality PTFE micro-transparent piping with excellent corrosion and adsorption resistance.
Automatically calculates the sampling height, at the moment of sampling can be based on the volume of solvent in accordance with the pharmacopoeia, in the position of accurate sampling.
Equipped with a secondary filter interface, more adequate solvent filtration.
Adoption of German syringes, automatic rinsing, filling, waste liquid disposal, sampling, back filling, emptying and other steps to ensure the sampling accuracy, while ensuring that the pipe line residue as little as possible.
One-click automatic cleaning of the liquid tank and pipeline after the completion of the.experiment to ensure no cross-contamination.
Continuous sampling, dual sample sampling.automatic sample dilution and other functions.
Automatically lubricates piping and sampling pumps before sampling to ensure sample accuracy.
Technical Parameter of DW-MDS-2008 Auto Sampler
| Performance parameter | Single sampling volume: 0.1-15mL (single); 0.2-30mL (double) | Dimensions | ≈515x660x460mm |
| Sampling frequency: 1-16 times (single); 1-8 times (double) | Whole machine weight | ≈53Kg | |
| Sampling accuracy: + 0.8%(10mL) | Operation temperature | (10~30)℃ | |
| Instrumentfunctions | Fully automatic lubrication, filling, dripping, sampling, replenishment, dilution, emptying, and cleaning | Storage temperature | (-20~60)℃ |
| Accurate sampling with injection pump, adjustable suction stop time | Working humidity | (20~80)% RH | |
| Input power supply | 220VAC+10% 200W | Storage humidity | (5~95)% RH |
DW-MDS-2008T Mechanical Verification Tools
MDS-2008T Mechanical verification Toolbox is a set of mechanical parameter testing device for dissolution meter in accordance with the “Guideline for Mechanical validation of Drug Dissolution Meter” developed by the state Food and Drug Administration, which is applicable to the calibration of all series of Drawell Dissolution tester and standard dissolution test of other manufacturers.
Technical Parameter of DW-MDS-2008T Mechanical Verification Tools
| Inspection items: | Levelness, verticality, coaxiality, depth, speed, oscillation, temperature and other parameters. |
| Resolution: | Coaxiality, depth, oscillation: 0.01mm |
| Temperature: 0.1℃ | |
| Verticality: 0.01o | |
| Stirring speed: 0.01rpm | |
| Provide special validation software to automatically record and judge the validation effect. | |
